Scientific Updates

Read regular medical and clinical updates on helicobacter related issues curtosy of medworm (www.medworm.com). 

• March 09, 2010, 08:15

  Molecular detection of host cytokine expression in

  Hosseini M Eshagh, Oghalaie A, Habibi G, Nahvijoo A, Hosseini Z M, Tashakoripoor M, Mohammadi MIndian Journal of Medical Microbiology 2010 28(1):40-44Background: Helicobacter pylori (Hp) is a bacterium recognised as a main causative agent for the development of chronic active gastritis, peptic ulcer disease, gastric adenocarcinoma and primary gastric lymphoma. Objective: Determination of the levels of IFN-γ (pro-inflammatory) and IL-4 (anti inflammatory) cytokine expression as indicators of Th1 and Th2 immune responses in gastric cancer (GC) and non gastric cancer (Non GC) dyspeptic patients by gene specific RT-PCR. Materials and Methods: Biopsy specimens were collected from three groups of gastric cancer (GC=18), non ulcer dyspepsia (NUD = 38) and peptic ulcer patients (PU...
• March 09, 2010, 05:34

  Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of

  Conclusion: One week of furazolidone in combination with 2 weeks of amoxicillin, omeprazole, and bismuth subcitrate is a safe and cost-effective regimen for the eradication of H pylori. Adding metronidazole to the above regimen does not increase the eradication rate. (Source: The Saudi Journal of Gastroenterology)
• March 09, 2010, 05:27

  Type 2 diabetes mellitus: A risk factor for

  Conclusion: Diabetic patients are more prone and at risk to acquire H. Pylori infection. Therefore proper monitoring of blood glucose level and screening for H. pylori infection are effective preventive measures for this life threatening infection. (Source: International Journal of Diabetes in Developing Countries)
• March 06, 2010, 08:00

  Breastfeeding protects children against peptic ulcer bacterium

  (University of Gothenburg) Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrens´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection. The results provide hope for a vaccine, according to research from the Sahlgrenska Academy at the University of Gothenburg, Sweden. (Source: EurekAlert! - Medicine and Health)
• March 05, 2010, 05:00

  Calbiotech Inc - H. Pylori IgM ELISA 96 Well Kit - Class 2 Recall

  H. Pylori IgM ELISA 96 Well Kit, Catalog Number: HP015M The products in question are all Enzyme Linked Immunosorbent Assay (ELISA) Test kits designed and marketed for Research Use Only. (Source: Medical Device Recalls since July 07, 2006)
• March 05, 2010, 05:00

  Calbiotech Inc - H. Pylori IgA ELISA 96 Well Kit - Class 2 Recall

  H. Pylori IgA ELISA 96 Well Kit, Catalog Number: HP014A The products in question are all Enzyme Linked Immunosorbent Assay (ELISA) Test kits designed and marketed for Research Use Only. (Source: Medical Device Recalls since July 07, 2006)

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• March 05, 2010, 05:02

  Etiological approach to chronic urticaria

  Conclusion:</b> Nearly half of the patients had chronic autoimmune urticaria on the basis of ASST. A significant number of them had serological makers of autoimmune activity. ASST provides an easy, inexpensive investigation in CU and helps direct attention to underlying systemic auto immune diseases. The presence of these auto antibodies was significantly associated with more frequent and longer lasting urticarial attacks. Exhaustive work ups with extensive laboratory diagnostics, challenge tests, and prick testing should be reserved for individual cases following detailed history. (Source: Indian Journal of Dermatology)
• March 04, 2010, 02:00

  Bismuth-Based First-Line Therapy for Helicobacter pylori Eradication in Type 2 Diabetes Mellitus Patients

  Digestion 2010;82:47–53 (DOI:10.1159/000236024) (Source: Digestion)
• March 04, 2010, 06:11

  Helicobacter pylori with or without its neutrophil-activating protein may be the common denominator associated with multiple sclerosis and neuromyelitis optica

  (Source: Multiple Sclerosis)
• March 04, 2010, 06:11

  Authors' reply to 'Helicobacter pylori with or without its neutrophil-activating protein may be the common denominator associated with multiple sclerosis and neuromyelitis optica'

  (Source: Multiple Sclerosis)
• March 04, 2010, 01:00

  Gene regulation: Can we stomach it? New technique fights against cause of peptic ulcer disease and gastric cancer

  A breakthrough in decoding gene regulation of Helicobacter pylori has been made by an international research team. Using a newly developed sequencing technique, the researchers discovered 60 small ribonucleic acids -- tiny RNA-particles which can regulate genes -- in the genome of this human pathogen. These findings could facilitate the development of new therapeutic strategies against this widespread pathogen. (Source: ScienceDaily Headlines)

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• March 03, 2010, 03:00

  Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation

  In conclusion, Cdx2 reduced Shh expression by binding to the unmethylated Shh promoter in the intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach. (Source: BJ Disease)
• March 03, 2010, 03:00

  Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation.

  In conclusion, Cdx2 reduced Shh expression by binding to the unmethylated Shh promoter in the intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach. PMID: 20199401 [PubMed - as supplied by publisher] (Source: The Biochemical Journal)
• March 03, 2010, 05:26

  Role of Probiotics in Pediatric Patients with Helicobacter pylori Infection: A Comprehensive Review of the Literature

  Conclusion: Both in vitro and in vivo studies provide evidence that probiotics may represent a novel approach to the management of H. pylori infection. (Source: Helicobacter)
• March 02, 2010, 03:00

  Associations Between Helicobacter pylori Infection, Co-Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

  Conclusions: There is a high prevalence of asymptomatic H. pylori infection in recently resettled African refugee children. Gastrointestinal symptoms were not predictive of H. pylori nor of helminth infections. Serum cytokines, particularly IL-5, IL-10, and TNF[alpha], were significantly elevated in children with malaria and helminth infections but not in those with H. pylori infection. (Source: Helicobacter)