Scientific Updates

Read regular medical and clinical updates on helicobacter related issues courtesy of medworm (www.medworm.com). 

• February 02, 2012, 03:26

  Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori.

  CONCLUSION: The levofloxacin-containing sequential therapy is a significantly better strategy than the standard triple treatment for H. pylori eradication. Standard triple treatment is no more effective for H. pylori in our population and levofloxacin-containing sequential regimen might be used as a first-line eradication option. PMID: 22284248 [PubMed - in process] (Source: European Journal of Internal Medicine)
• February 02, 2012, 10:21

  Ulcer-causing bug tied to higher diabetes risk

  NEW YORK (Reuters Health) - People who have been infected with the ulcer-causing bacteria Helicobacter pylori are more than twice as likely to develop diabetes later on as people who do not have signs of the infection, according to a new study of Latino adults in California. (Source: Reuters: Health)
• February 02, 2012, 10:21

  Ulcer-Causing Bug Tied to Higher Diabetes Risk

  People who have been infected with the ulcer-causing bacteria Helicobacter pylori are more than twice as likely to develop diabetes later on as people who do not have signs of the infection, according to a new study of Latino adults in California.Source: Reuters Health Related MedlinePlus Pages: Diabetes, Peptic Ulcer (Source: MedlinePlus Health News)
• February 02, 2012, 04:55

  Bile Salts for the Treatment of Heart Failure: Out on a Limb for a Gut Feeling?⁎

  In 1984, Warren and Marshall () presented indirect evidence of a putative microbial etiology for peptic ulcer disease. In the decades to follow, >37,000 scholarly articles have been published on Helicobacter pylori (). Unlike the discovery of the role of H pylori in peptic ulcer disease, enthusiasm for infectious causes of all manner of cardiovascular disease has been largely unsubstantiated (). Nevertheless, the robust relationship between inflammation and cardiovascular events lends biological plausibility to the possible association between infectious processes and cardiovascular disease, particularly heart failure (). Tumor necrosis factor (TNF)-α, interleukin (IL)-6, and other inflammatory cytokines have been recognized as correlates of heart failure disease progression and severity,...
• January 31, 2012, 08:00

  Med Sci Monit 2012; 18(2):BR84-88 "Lack of association of conjunctival MALT lymphoma with Chlamydiae or Helicobacter pylori in a cohort of Chinese patients"

  Conclusions: The PCR technique was able to detect the positive control quickly and accurately, but the results of PCR in analyzing the 16 specimens were negative, indicating that there is no association between conjunctival MALT lymphoma and the 4 microorganisms in Chinese patients. (Source: Medical Science Monitor)
• January 31, 2012, 08:00

  Med Sci Monit 2012; 18(2):CR125-130 "Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: A randomized, open-labeled, two-way crossover study"

  Conclusions: Intravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole. (Source: Medical Science Monitor)

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• January 31, 2012, 08:00

  Helicobacter pylori may play a role in both obstructive sleep apnea and metabolic syndrome

  To the Editor We read with interest the paper by Theorell-Haglöw et al. , which concluded that obstructive sleep apnea (OSA) is closely associated with metabolic syndrome and its components in a Swedish population. (Source: Sleep Medicine)
• January 31, 2012, 08:00

  What is cause and what is effect?

  We would like to thank Prof. Kountouras and co-workers for their interest in our article . Kountouras et al. raise the question whether Helicobacter pylori infection (Hp-I) could be a potential confounder involved in obstructive sleep apnea (OSA) and gastroesophageal reflux disease (GERD) pathophysiology associated with metabolic syndrome. The concept is interesting as OSA, GERD and metabolic syndrome are all common disorders. (Source: Sleep Medicine)
• January 30, 2012, 08:00

  Histological features of the gastric mucosa in children with primary bile reflux gastritis

  Conclusions: Foveolar hyperplasia was associated with the severity of bile reflux, suggesting that it is a histological feature of primary BRG in children, while vascular congestion may be a protective factor. (Source: World Journal of Surgical Oncology)
• January 30, 2012, 08:00

  Serological Assessment of gastric mucosal Atrophy in gastric Cancer.

  Background: Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1(PG1), pepsinogen 2 (PG2) and gastrin 17 (G17) offers the possibility to detect preneoplastic gastric mucosal conditions. Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia. Methods: Histological and serological samples of 118 patients with gastric cancer have been assessed for tumor specific characteristics (Lauren type, localisation), degree of mucosal abnormalities (intestinal metaplasia, atrophy) and serological parameters (PG1, PG2, PG1/2-ratio, G17, H. pylori IgG, CagA status). Association of the general factors to the different serological values have been statistically analyzed. Resu...
• January 30, 2012, 08:00

  A multicenter validation of an endoscopic classification with narrow band imaging for gastric precancerous and cancerous lesions

  Conclusion: A simplified NBI classification is accurate and reliable for the diagnosis of intestinal metaplasia and dysplasia. The classification should be further assessed and validated on a per-patient assessment of NBI, and by comparing NBI with other imaging technologies. [...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Endoscopy)

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• January 30, 2012, 08:00

  Microbial and histopathologic considerations in the use of mouse models of inflammatory bowel diseases

  AbstractAbstract:Mouse models provide powerful tools to investigate disease mechanisms and are widely used in inflammatory bowel disease research. However, it is common for reports of mouse model studies to lack potentially important information about the microbial status of the mice and the method used to evaluate disease expression for statistical analysis. For example, it is common practice to state that the mice were housed under specific pathogen‐free conditions but provide no further information regarding the presence or absence of organisms such as Helicobacter spp. that are known or likely to affect disease expression, thus omitting information potentially important to the expected phenotype of the mice and their responses to experimental manipulation. We therefore encourage auth...
• January 30, 2012, 08:00

  Helicobacter pylori Infection and Colorectal Cancer Risk: Evidence From a Large Population-based Case-Control Study in Germany.

  Authors: Zhang Y, Hoffmeister M, Weck MN, Chang-Claude J, Brenner H Abstract Evidence concerning the role of Helicobacter pylori infection in the development of colorectal cancer remains controversial. The authors assessed the association of H. pylori seroprevalence with risk of colorectal cancer in a large population-based case-control study from Germany in 2003-2007. Serum antibodies to H. pylori in general and the cytotoxin-associated gene A protein (CagA) were measured in 1,712 incident colorectal cancer cases and 1,669 controls. The association between H. pylori seroprevalence and colorectal cancer risk was estimated by logistic regression, with adjustment for potential confounders and stratification by age group, sex, anatomic subsites, and cancer stage. Overall, H. pylori se...
• January 30, 2012, 07:04

  Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

  Conclusions  Asymptomatic NG is associated with H. pylori infection, and a predilection for this condition exists in young females. The PR3 expression of gastric mucosa might play an important role in the pathogenesis of NG. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s10620-012-2053-3Authors Sung Noh Hong, Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729 Republic of KoreaSeunghyun Jo, Department of Biomedical Science and Technology, Medical Immunology Center, Konkuk University, Seoul, KoreaJu Hyun Jang, Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729 Republic of KoreaJida Choi, Department of Biomedic...
• January 29, 2012, 08:00

  Superoxide dismutase activity of Helicobacter pylori per se from 158 clinical isolates and the characteristics

  ABSTRACTOur aims are to investigate the correlation between superoxide dismutase (SOD) activity of Helicobacter pylori (H. pylori) and gastroduodenal diseases and the characteristics of strains exposed to oxidative stress. Two sequenced strains, 26695 and J99, and clinical isolates from 156 Japanese patients with gastroduodenal diseases such as gastric cancer (n = 59) and non‐cancer (n = 97) were utilized. SOD activities of all 158 isolates were measured by a SOD Assay Kit‐WST and were divided into 3 groups; high‐SOD activity (>0.22, n = 2), moderate‐SOD activity (0.15≦　≦0.22, n = 16) and low‐SOD activity (<0.15, n = 140) groups. The expressions of H. pylori iron‐cofactored SOD (Fe‐SOD) were examined by western blotting with anti‐H. pylori Fe‐SOD antibody prep...